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Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
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Biomonitoring equivalents for DDT/DDE.

Christopher R Kirman1, Lesa L Aylward, Sean M Hays

  • 1Summit Toxicology, LLP, Orange Village, OH, USA.

Regulatory Toxicology and Pharmacology : RTP
|April 7, 2011
PubMed
Summary

Biomonitoring Equivalents (BEs) for DDT and its metabolites were established using health risk assessments. These BE values serve as screening tools for evaluating population biomonitoring data and prioritizing further risk assessments.

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Area of Science:

  • Environmental Health
  • Toxicology
  • Biomonitoring

Background:

  • Biomonitoring Equivalents (BEs) link chemical concentrations in biological samples to health-based exposure guidelines.
  • DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) and its metabolites (DDE, DDD) are persistent environmental contaminants.
  • Existing risk assessments from organizations like WHO and US EPA provide guidance for chemical exposure.

Purpose of the Study:

  • To review health-based risk assessments for DDT, DDE, and DDD.
  • To derive Biomonitoring Equivalents (BEs) for DDT and its metabolites.
  • To establish screening tools for population biomonitoring data of DDT compounds.

Main Methods:

  • Literature review of health-based risk assessments and exposure guidance values for DDT and metabolites.
  • Utilized toxicokinetic data and human elimination half-lives to estimate BE values.
  • Calculated lipid-adjusted blood/serum/plasma concentrations for BEs based on non-cancer and cancer risk levels.

Main Results:

  • Non-cancer BE values for the sum of DDT, DDE, and DDD range from 5000 to 40,000 ng/g lipid.
  • BE values for a 1E-05 cancer risk level are 300 ng/g lipid for DDT and 500 ng/g lipid for DDE (US EPA assessment).
  • Identified uncertainties in BE value derivation and application for biomonitoring data evaluation.

Conclusions:

  • Derived BE values can effectively screen population biomonitoring data for DDT and related compounds.
  • These BEs aid in contextualizing biomonitoring results within existing risk assessments.
  • The study supports prioritization for further risk assessment efforts concerning DDT.