Related Experiment Video
Updated: Jun 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Adalimumab-induced interstitial pneumonia with an improvement of pre-existing rheumatoid arthritis-associated lung
Kosaku Komiya1, Hiroshi Ishii, Naoko Fujita
1Internal Medicine 2, Oita University Faculty of Medicine, Japan.
Abstract:
A 78-year-old man with an 18-year history of rheumatoid arthritis (RA) was treated with tumor necrosis factor (TNF)-α inhibitor adalimumab. Chest computed tomography showed a previously detected consolidation. The patient's arthritic symptoms substantially decreased with the initiation of adalimumab, with a simultaneous improvement of the lung lesion. However, additional interstitial pneumonia was found a month after starting adalimumab. This course suggested that adalimumab might be effective against RA-associated lung disease, but may also have caused drug-induced interstitial pneumonia. This is the first report indicating that TNF-α inhibitor shows simultaneously conflicting actions in a patient with RA-related lung disease.
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