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Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: Jun 3, 2026

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice

Published on: September 29, 2023

Does notch size predict ACL insertion site size?

Femke Wolters¹, Sharon H A Vrooijink, Carola F Van Eck

¹Department of Orthopaedic Surgery, University of Pittsburgh, Kaufmann Bldg Ste 1011, 3471 Fifth Ave, Pittsburgh, PA 15213-3221, USA.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA

|April 7, 2011

Summary

A weak correlation exists between femoral intercondylar notch width and anterior cruciate ligament (ACL) insertion site size. Women generally have smaller notches and insertion sites than men, impacting surgical graft choices.

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Area of Science:

Orthopedic Surgery
Anatomy
Biomedical Engineering

Background:

The femoral intercondylar notch houses the anterior cruciate ligament (ACL).
Notch dimensions may influence ACL integrity and reconstruction outcomes.
Understanding notch and ACL insertion site morphology is crucial for surgical planning.

Purpose of the Study:

To investigate the correlation between femoral intercondylar notch width and ACL insertion site size.
To determine sex-based differences in notch width and ACL insertion site dimensions.

Main Methods:

Arthroscopic measurements of notch width and height were performed in 82 patients (41 male, 41 female) undergoing ACL reconstruction.
ACL insertion sites were identified, marked, and measured.
Statistical analysis was used to assess correlations and sex differences.

Main Results:

A significant positive correlation (r=0.222-0.379, P<0.05) was observed between notch width and ACL insertion site size.
Significant differences in both notch and insertion site sizes were found between male and female patients.

Conclusions:

A weak but significant correlation exists between femoral intercondylar notch width and ACL insertion site size.
Women exhibit smaller notch and ACL insertion site dimensions compared to men.
These findings may inform pre-operative decisions regarding graft selection and surgical technique in ACL reconstruction.