Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Withdrawn: Housing Systems (Loose Housing vs. Tie Stalls) Effect on Animal Welfare, Carcass Characteristics, and Meat Quality of Different Parts of Muscle in the Finishing Beef Bulls.

Food science of animal resources·2026
Same author

Corrigendum to "LRH1 promotes pancreatic cancer metastasis" [Cancer Lett. (2014) 24 350 (1-2) 15-24].

Cancer letters·2026
Same author

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).

International journal of molecular medicine·2026
Same author

An Immersive P300 Brain-Computer Interface Based on 3D Morphological Stimuli and Self-Adaptive Bayesian Linear Discriminant Analysis.

Biomimetics (Basel, Switzerland)·2026
Same author

Neoadjuvant immunochemotherapy followed by definitive radiotherapy in locally advanced head and neck squamous cell carcinoma: two-year survival outcomes.

Cancer immunology, immunotherapy : CII·2026
Same author

Glycolytic reprogramming in host response to <i>Borrelia burgdorferi</i>: A gene signature revealed by integrative bioinformatics analysis and machine learning.

Experimental and therapeutic medicine·2026
Same journal

mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes.

Protein & cell·2026
Same journal

Targeting the TBK1-p62 condensate axis restores sensitivity to EGFR-TKIs in resistant lung cancer.

Protein & cell·2026
Same journal

Recent progresses in cancer multidrug resistance and therapeutic options associated with protein damage response.

Protein & cell·2026
Same journal

LncRNA Gas5 directs SUV39H2 to establish heterochromatin and maintain genome stability.

Protein & cell·2026
Same journal

3D chromatin dynamics in cellular neuroendocrine transformation.

Protein & cell·2026
Same journal

Topology-Driven Activation of the GLP-1 Receptor Promotes Adipose Tissue Browning.

Protein & cell·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Directed hepatic differentiation from embryonic stem cells.

Xuesong Chen1, Fanyi Zeng

  • 1Laboratory of Developmental Biology, Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Protein & Cell
|April 7, 2011
PubMed
Summary
This summary is machine-generated.

Generating hepatocytes from embryonic stem cells offers a promising solution for liver disease treatments, addressing donor shortages. Understanding embryonic liver development is key to this in vitro differentiation strategy.

More Related Videos

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System
07:09

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Published on: May 10, 2020

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
05:49

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Related Experiment Videos

Last Updated: Jun 3, 2026

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System
07:09

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Published on: May 10, 2020

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
05:49

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Area of Science:

  • * Developmental Biology
  • * Stem Cell Biology
  • * Hepatology

Background:

  • * The liver, the largest internal organ in mammals, is vital for physiological homeostasis.
  • * Chronic liver diseases (hepatitis, cirrhosis, cancer) pose significant health risks.
  • * Limited liver donor availability hinders transplantation therapies.

Purpose of the Study:

  • * To describe embryonic liver development (hepatogenesis) in vivo.
  • * To discuss the directed differentiation of embryonic stem cells into hepatocytes in vitro.
  • * To provide insights for cell-based therapies for liver diseases.

Main Methods:

  • * Review of in vivo embryonic hepatogenesis.
  • * Discussion of in vitro directed differentiation protocols for stem cells.
  • * Comparative analysis of developmental processes.

Main Results:

  • * Detailed description of the stages and signaling pathways involved in embryonic liver formation.
  • * Overview of current strategies for inducing stem cell differentiation into functional hepatocytes.
  • * Identification of key factors influencing hepatocyte development.

Conclusions:

  • * Understanding in vivo hepatogenesis is crucial for optimizing in vitro stem cell differentiation.
  • * Directed differentiation of embryonic stem cells presents a viable alternative for generating hepatocytes for transplantation.
  • * Further research can advance cell-based therapies for liver disease and reduce reliance on donor organs.