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Related Experiment Video

Updated: Jun 3, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Model-based discovery of circulating biomarkers.

Maryann S Vogelsang1, Kian Kani, Jonathan E Katz

  • 1University of Southern California, University of California, Los Angeles, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 7, 2011
PubMed
Summary

This study introduces a novel proteomic biomarker discovery method focusing on primary tissue or cell cultures, overcoming challenges associated with serum and plasma analysis for improved patient stratification.

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Area of Science:

  • Biochemistry
  • Proteomics
  • Biomarker Discovery

Background:

  • Proteomic biomarker discovery aims to identify proteins that differentiate patient populations.
  • Current methods often analyze serum or plasma, facing challenges due to high complexity and dynamic protein ranges.
  • Alternative approaches are needed to overcome these limitations in biomarker identification.

Purpose of the Study:

  • To present a novel approach for biomarker discovery.
  • To focus on profiling primary tissue or cell culture models for marker identification.
  • To circumvent the challenges associated with analyzing complex serum and plasma samples.

Main Methods:

  • Proteomic analysis of primary tissue samples.
  • Proteomic analysis of cell culture models.

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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

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Last Updated: Jun 3, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

  • Development of methods to simplify or fractionate complex biological samples.

    • Main Results:

    • The study describes a new strategy for biomarker discovery.
    • This approach focuses on tissue or cell culture profiling.
    • It offers an alternative to direct serum or plasma analysis.

    Conclusions:

    • Profiling primary tissue or cell cultures provides a viable alternative for proteomic biomarker discovery.
    • This method addresses the limitations of serum and plasma analysis.
    • The described approach facilitates the identification of organ-specific biomarkers.