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Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

Overview
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

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Updated: Jun 3, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Immunometabolism: an emerging frontier.

Diane Mathis1, Steven E Shoelson

  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. dm@hms.harvard.edu

Nature Reviews. Immunology
|April 8, 2011
PubMed
Summary
This summary is machine-generated.

Immunometabolism explores the link between immunology and metabolism. Understanding how obesity-induced inflammation impacts chronic diseases offers new therapeutic strategies.

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Area of Science:

  • The interdisciplinary field of immunometabolism investigates the intricate relationship between the immune system and metabolic processes.

Background:

  • The rising obesity epidemic highlights the immune system's susceptibility to metabolic dysfunction.
  • Obesity-induced inflammation is increasingly recognized as a driver of various chronic conditions and diseases.

Discussion:

  • Multilevel interactions between metabolic and immune systems reveal pathogenic mechanisms underlying obesity complications.
  • This field offers significant potential for developing novel therapeutic interventions.

Key Insights:

  • Obesity profoundly impacts immune cell function and systemic inflammation.
  • Inflammation driven by metabolic dysregulation contributes to chronic disease pathogenesis.

Outlook:

  • Further research into immunometabolism promises to uncover new therapeutic targets for obesity-related diseases.
  • Harnessing insights from immunometabolism could lead to innovative treatments for chronic inflammatory conditions.