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Coffee, caffeine and hemostasis: results from two randomized studies
A A Bak1, H H van Vliet, D E Grobbee
1Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
Insights
Coffee and caffeine consumption do not significantly impact key blood clotting factors like fibrinogen or factor VII activity in healthy adults. These findings suggest no adverse effects on hemostasis from moderate intake.
Area of Science:
- Cardiovascular Health
- Nutritional Science
- Hematology
Background:
- Hemostasis is a complex process involving blood clotting factors.
- Coffee and caffeine are widely consumed globally.
- Previous research on coffee's effect on hemostasis has yielded mixed results.
Purpose of the Study:
- To investigate the influence of coffee and caffeine consumption on specific hemostatic factors.
- To assess the impact of different coffee preparations (filtered vs. boiled) and pure caffeine intake on blood coagulation.
Main Methods:
- Two randomized controlled trials were conducted involving young, healthy adults.
- Study 1: 107 participants consumed filtered coffee, boiled coffee, or no coffee for 9 weeks.
- Study 2: 69 participants received caffeine tablets or placebo in a double-blind, decaffeinated coffee setting.
Main Results:
- Coffee consumption showed no significant effect on fibrinogen, factor VII activity, factor VIII antigen, protein C, or protein S.
- Caffeine consumption did not alter fibrinogen levels or factor VII activity.
Conclusions:
- Neither coffee consumption nor caffeine intake appears to influence key hemostatic factors in young, healthy individuals.
- These findings contribute to understanding the cardiovascular implications of regular coffee and caffeine consumption.
Abstract:
The influence of coffee and caffeine consumption on hemostatic factors was studied in 2 randomized trials. Both studies were conducted in young, healthy adults. In the first study, 107 participants were randomly allocated to one or 3 intervention groups, drinking filtered coffee, boiled coffee or no coffee at all, respectively, for a period of 9 weeks. In the second study, 69 subjects received either 4-6 tablets containing 75 mg caffeine or the same amount of placebo tablets, while using decaffeinated coffee. In this double-blind study caffeine intake from any other source was not allowed. Blood samples for hemostatic factors were obtained at baseline and after 9 weeks of intervention. The findings indicate no effect of coffee consumption on fibrinogen, clotting factor VII activity, factor VIII antigen, protein C and protein S and also no effect of caffeine consumption on fibrinogen and factor VII activity.