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Related Experiment Videos

Coffee, caffeine and hemostasis: results from two randomized studies.

A A Bak1, H H van Vliet, D E Grobbee

  • 1Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

Atherosclerosis
|August 1, 1990
PubMed
Summary

Coffee and caffeine consumption do not significantly impact key blood clotting factors like fibrinogen or factor VII activity in healthy adults. These findings suggest no adverse effects on hemostasis from moderate intake.

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Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Hematology

Background:

  • Hemostasis is a complex process involving blood clotting factors.
  • Coffee and caffeine are widely consumed globally.
  • Previous research on coffee's effect on hemostasis has yielded mixed results.

Purpose of the Study:

  • To investigate the influence of coffee and caffeine consumption on specific hemostatic factors.
  • To assess the impact of different coffee preparations (filtered vs. boiled) and pure caffeine intake on blood coagulation.

Main Methods:

  • Two randomized controlled trials were conducted involving young, healthy adults.
  • Study 1: 107 participants consumed filtered coffee, boiled coffee, or no coffee for 9 weeks.
  • Study 2: 69 participants received caffeine tablets or placebo in a double-blind, decaffeinated coffee setting.

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Main Results:

  • Coffee consumption showed no significant effect on fibrinogen, factor VII activity, factor VIII antigen, protein C, or protein S.
  • Caffeine consumption did not alter fibrinogen levels or factor VII activity.

Conclusions:

  • Neither coffee consumption nor caffeine intake appears to influence key hemostatic factors in young, healthy individuals.
  • These findings contribute to understanding the cardiovascular implications of regular coffee and caffeine consumption.