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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: Jun 3, 2026

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
08:06

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

Metastasis suppressors: basic and translational advances.

C Buchanan1, M A Lago Huvelle, M G Peters

  • 1Research Area. Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina.

Current Pharmaceutical Biotechnology
|April 8, 2011
PubMed
Summary
This summary is machine-generated.

Metastasis suppressors are proteins that inhibit cancer spread and are key therapeutic targets. Understanding these molecules offers new strategies to improve patient treatment outcomes and reduce cancer mortality.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Tumor metastasis is a primary cause of cancer-related deaths.
  • Metastasis suppressors represent a novel class of molecules with the potential to reduce cancer spread.

Purpose of the Study:

  • To review the current understanding of metastasis suppressors.
  • To explore the therapeutic potential of metastasis suppressors in improving cancer treatment.

Main Methods:

  • Literature review of metastasis suppressor functions.
  • Analysis of the role of metastasis suppressors in the metastatic cascade.

Main Results:

  • Metastasis suppressors regulate critical steps of metastasis, including cell invasion and colonization.
  • These proteins are crucial for preventing cancer cell survival in circulation and at distant sites.

Conclusions:

  • Metastasis suppressors are vital targets for developing new cancer therapies.
  • Further research into metastasis suppressors can lead to improved clinical strategies for managing metastatic cancer.