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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jun 3, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Cell penetrating peptides for tumor targeting.

Young Suk Choi1, Jue Yeon Lee, Jin Sook Suh

  • 1Department of Dental Regenerative Biotechnology, Dental Research Institute and School of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.

Current Pharmaceutical Biotechnology
|April 8, 2011
PubMed
Summary

Cell penetrating peptides (CPPs) enhance anticancer drug delivery by improving cell membrane permeability. These peptides offer a promising strategy for targeted tumor therapy and intracellular delivery of various molecular cargoes.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nanotechnology

Background:

  • Anticancer drug delivery faces challenges with cell membrane permeability and tumor cell targeting.
  • Bioavailability of anticancer drugs is critically dependent on efficient cell permeability for therapeutic efficacy.
  • Cell penetrating peptides (CPPs) are effective tools for intracellular drug delivery, overcoming traditional barriers.

Purpose of the Study:

  • To discuss the classification and cell entry mechanisms of CPPs.
  • To explore the application of CPPs in tumor therapy.
  • To highlight recent advances in targeted cell penetration using CPPs.

Main Methods:

  • Review of existing literature on CPP classification and mechanisms.
  • Analysis of CPP applications in preclinical and clinical tumor models.
  • Examination of novel strategies for targeted CPP-mediated delivery.

Main Results:

  • CPPs, often short peptides with basic residues, facilitate intracellular delivery of diverse cargo, including nanoparticles.
  • While CPP cell entry mechanisms require further elucidation, their utility in drug delivery is established.
  • Targeted CPPs show potential for selective delivery to tumor cells, improving therapeutic outcomes.

Conclusions:

  • CPPs represent a significant advancement in overcoming cell permeability barriers for anticancer drug delivery.
  • Further research into CPP mechanisms and targeted delivery will enhance their role in oncology.
  • CPPs offer a versatile platform for the intracellular delivery of therapeutic agents and nanoparticles in cancer treatment.