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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
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Published on: November 7, 2018

Diarrheagenic pathogens in polymicrobial infections.

Brianna Lindsay1, T Ramamurthy, Sourav Sen Gupta

  • 1University of Maryland Baltimore, Baltimore, Maryland, USA.

Emerging Infectious Diseases
|April 8, 2011
PubMed
Summary
This summary is machine-generated.

Diarrhea in Indian patients often involves multiple pathogens. Vibrio cholerae O1 and rotavirus co-infections showed complex, non-random associations with other gastrointestinal pathogens, the reasons for which are unknown.

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Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Microbiology

Background:

  • Diarrhea remains a significant cause of morbidity worldwide.
  • Identifying causative pathogens is crucial for effective treatment and control.
  • Polymicrobial infections are common but their dynamics are not fully understood.

Purpose of the Study:

  • To investigate the prevalence of multiple gastrointestinal pathogens in diarrhea patients.
  • To analyze the associations between specific pathogens, particularly Vibrio cholerae O1 and rotavirus, and other co-infecting agents.
  • To determine if these associations are influenced by patient age or season.

Main Methods:

  • Systematic active surveillance of 2,748 patients admitted with diarrhea.
  • Testing fecal samples for 26 known gastrointestinal pathogens.
  • Statistical analysis to identify non-random associations between pathogens, stratified by age and season.

Main Results:

  • Approximately 29% of patients had samples with multiple pathogens.
  • Polymicrobial infections frequently involved Vibrio cholerae O1 and rotavirus.
  • Significant non-random associations (both increased and decreased detection rates) were observed between V. cholerae O1/rotavirus and other pathogens, persisting after stratification.

Conclusions:

  • Multiple gastrointestinal pathogen infections are common in diarrhea patients in Kolkata, India.
  • The co-occurrence of Vibrio cholerae O1 and rotavirus with other pathogens is non-random.
  • The underlying causes and clinical implications of these complex pathogen interactions require further investigation.