Related Experiment Video

Updated: Jun 3, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006

Chee Fu Yung1, Nick Andrews, Antoaneta Bukasa

  • 1Health Protection Agency Centre for Infections, London, UK. cheefu.yung@gmail.com

Emerging Infectious Diseases
|April 8, 2011
PubMed

Insights

Mumps vaccination significantly reduced the risk of severe mumps complications like orchitis and meningitis during a large outbreak. One dose of the measles, mumps, and rubella vaccine offered protection against hospitalization and disease severity.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • The 2004-2005 mumps outbreak in England and Wales represented a significant public health challenge.
  • Understanding mumps complications and the impact of vaccination is crucial for effective control strategies.

Purpose of the Study:

  • To assess mumps complications during a major outbreak in England and Wales.
  • To evaluate the association between mumps vaccination and disease severity.

Main Methods:

  • Analysis of hospital admission data and enhanced mumps surveillance.
  • Comparison of complication rates during the outbreak versus non-outbreak periods.
  • Statistical analysis of vaccination's effect on hospitalization and specific complications.

Main Results:

  • The outbreak saw increased hospitalizations for orchitis, meningitis, and pancreatitis.
  • Vaccination with one dose of measles, mumps, and rubella vaccine reduced the risk of hospitalization (OR 0.54), mumps orchitis (OR 0.72), and mumps meningitis (OR 0.28).
  • Enhanced surveillance indicated lower hospitalization and complication rates compared to routine data.

Conclusions:

  • Mumps vaccination provides a protective effect against severe disease and its complications.
  • Vaccination is critical for assessing the overall impact of mumps control strategies.
  • Public health interventions should consider the role of vaccination in mitigating outbreak severity.

More Related Videos

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...