Related Experiment Video
Updated: Jun 3, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Age-related macular degeneration and the other double helix. The Cogan Lecture
1Department of Ophthalmology and Vision Sciences, University of Kentucky, 740 S. Limestone Street, Lexington, KY 40536-0284, USA. jamba2@email.uky.edu
Abstract:
The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD.
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