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Updated: Jun 3, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
New treatment modalities in advanced thyroid cancer
E Kapiteijn1, T C Schneider1, H Morreau2
1Departments of Clinical Oncology.
Summary
New therapies are emerging for advanced thyroid cancer, including targeted agents and immunotherapies. Ongoing research and clinical trials are exploring novel treatment modalities to improve patient outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Clinical Trials
Background:
- Thyroid cancer is a complex disease with subtypes including differentiated (DTC), undifferentiated/anaplastic (ATC), and medullary carcinoma.
- Conventional treatments for advanced thyroid cancer have yielded limited success, necessitating the exploration of novel therapeutic strategies.
Purpose of the Study:
- To review and summarize recent advancements in treatment modalities for advanced thyroid cancer.
- To identify emerging therapies and ongoing clinical trials in the field.
Main Methods:
- Comprehensive literature search of databases including PubMed, Cochrane Library, Medline, and EMBASE.
- Inclusion of abstracts from annual proceedings and ongoing trials registered on clinicaltrials.gov.
- Focus on novel treatment approaches beyond conventional therapies.
Main Results:
- Multiple clinical trials investigated tyrosine kinase inhibitors (6 Phase I, 17 Phase II, 1 Phase III).
- Redifferentiation therapies (2 pilot, 11 Phase II) and antiproliferative approaches (3 Phase I, 4 Phase II) were explored, primarily in DTC.
- Immunomodulatory gene therapy (1 pilot study in ATC), immunotherapy (2 Phase II), and radionuclide therapy (1 Phase I, 9 Phase II in DTC) showed promise.
Conclusions:
- Significant developments in advanced thyroid cancer treatment are evident.
- Future research should focus on combination therapies, integrating targeted agents with other modalities.
- Optimizing treatment strategies holds potential for improved patient outcomes.
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