Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The enkephalins. Peptides with morphine-like activity.

R J Miller, P Cuatrecasas

    Die Naturwissenschaften
    |October 1, 1978
    PubMed
    Summary

    Newly discovered enkephalins, peptides with morphine-like effects, are found in the nervous system and gut. These compounds exhibit analgesic, anti-tussive, and anti-diarrheal properties, with synthetic versions showing broad activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Role of specific membrane lipids in modulating the activity of adenylate cyclase.

    Biophysical journal·2009
    Same author

    Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin.

    The Journal of biological chemistry·1995
    Same author

    Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.

    Proceedings of the National Academy of Sciences of the United States of America·1994
    Same author

    Picosecond phase grating spectroscopy of hemoglobin and myoglobin: energetics and dynamics of global protein motion.

    Biochemistry·1992
    Same author

    The actions of baclofen on neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro.

    The Journal of physiology·1992
    Same author

    Interwoven threads: occupational therapy, feminism, and holistic health.

    The American journal of occupational therapy : official publication of the American Occupational Therapy Association·1992

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Endocrinology

    Background:

    • Two endogenous penta-peptides with morphine-like properties, known as enkephalins, have been identified.
    • Enkephalins are unevenly distributed in the brain, with highest concentrations in the globus pallidus.
    • These peptides play roles in pain modulation, gastrointestinal function, and hormone regulation.

    Purpose of the Study:

    • To investigate the physiological roles and pharmacological properties of enkephalins.
    • To explore the potential of synthetic enkephalin analogues for therapeutic applications.

    Main Methods:

    • Identification and characterization of endogenous enkephalins in nervous and gastrointestinal tissues.
    • Assessment of analgesic, anti-tussive, and anti-diarrheal activities.
    • Development and evaluation of synthetic enkephalin analogues with specific D-amino acid substitutions.

    Main Results:

    • Enkephalins demonstrate significant analgesic properties.
    • Enkephalins exhibit anti-tussive and anti-diarrheal effects.
    • Enkephalins stimulate the release of prolactin and growth hormone.
    • Synthetic analogues display a wide spectrum of biological activities.

    Conclusions:

    • Enkephalins are key neurochemical modulators with diverse physiological functions.
    • Synthetic enkephalin analogues represent promising therapeutic agents for various conditions.
    • Further research into enkephalin pathways could yield novel pain management strategies.

    Related Experiment Videos