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Related Experiment Video

Updated: Jun 3, 2026

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
06:40

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Published on: April 5, 2024

Maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation R study.

Akhgar Ghassabian1, Jacoba J Bongers-Schokking, Jens Henrichs

  • 1The Generation R Study, and Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

Pediatric Research
|April 8, 2011
PubMed
Summary

Maternal thyroid-stimulating hormone (TSH) during pregnancy is linked to increased externalizing behaviors in children up to age 3. This suggests subtle thyroid function changes can impact child neurodevelopment and behavior.

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Last Updated: Jun 3, 2026

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period
06:40

Analysis of Electrocardiograms and Behavior in Mice from Pregnancy to Lactation Period

Published on: April 5, 2024

Area of Science:

  • Endocrinology
  • Neurodevelopmental Pediatrics
  • Perinatal Medicine

Background:

  • Maternal thyroid function during gestation influences fetal neurodevelopment.
  • Limited understanding exists regarding the specific impact of maternal thyroid parameters on offspring behavior.

Purpose of the Study:

  • To investigate the association between maternal thyroid function in early pregnancy and problem behaviors in children up to age 3.
  • To determine if maternal thyroid hormone levels predict specific behavioral outcomes in early childhood.

Main Methods:

  • Utilized data from the population-based Generation R study (3736 mother-child pairs).
  • Assessed maternal thyroid function (TSH, free T4, total T4) in the first half of pregnancy.
  • Evaluated child behavior using the Child Behavior Checklist at 1.5 and 3 years of age.

Main Results:

  • Elevated maternal thyroid-stimulating hormone (TSH) levels during pregnancy were associated with higher externalizing behavior scores in children at 1.5 and 3 years.
  • A linear relationship was observed between maternal TSH levels and externalizing scores across the TSH range.
  • Maternal free thyroxine and total thyroxine levels showed no significant association with child internalizing or externalizing scores.

Conclusions:

  • Subtle impairments in maternal thyroid function, specifically elevated TSH, may impact fetal brain development, leading to behavioral issues in offspring.
  • Maternal thyroid function is crucial for neurodevelopment and subsequent problem behavior in children.
  • Further research is warranted to explore the mechanisms linking maternal thyroid function and child behavior.