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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Related Experiment Video

Updated: Jun 3, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

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Published on: July 12, 2022

BAG3: a multifaceted protein that regulates major cell pathways.

A Rosati1, V Graziano, V De Laurenzi

  • 1Department of Pharmaceutical and Biomedical Sciences (FARMABIOMED), University of Salerno, Fisciano, Italy.

Cell Death & Disease
|April 8, 2011
PubMed
Summary

Bcl2-associated athanogene 3 (BAG3) is a stress-inducible co-chaperone protein. This review explores how BAG3 influences cell survival, adaptive responses, and tumor progression, highlighting its role in cancer development.

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Last Updated: Jun 3, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

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Published on: July 12, 2022

Bimolecular Fluorescence Complementation
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13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Bcl2-associated athanogene 3 (BAG3) is a co-chaperone protein interacting with heat shock protein 70.
  • BAG3 is uniquely induced by stress via heat shock factor 1, possessing domains for diverse molecular interactions.
  • It plays a role in cell adaptive responses, including apoptosis, cytoskeleton organization, and autophagy.

Purpose of the Study:

  • To review the emerging mechanisms of BAG3's biological activities.
  • To focus on the implications of BAG3 in tumor progression and cancer biology.

Main Methods:

  • Literature review of studies on BAG3 function and expression.
  • Analysis of BAG3's role in normal cellular processes and various cancer types.

Main Results:

  • BAG3 is constitutively expressed in specific normal cells like cardiomyocytes, aiding mechanical stress resistance.
  • BAG3 is upregulated in several tumor types, promoting cancer cell survival, therapy resistance, motility, and metastasis.
  • Down-modulation of BAG3 has shown potential in inhibiting tumor growth in preclinical models.

Conclusions:

  • BAG3's multifaceted interactions enable it to modulate critical cellular processes, contributing to stress adaptation.
  • BAG3's role in promoting cancer cell survival and progression makes it a potential therapeutic target in oncology.