Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Statescope: an integrative deconvolution framework for discovering cell states in tumors.

Nature communications·2026

Same author

Spatial analysis of malignant-immune cell interactions in the tumor microenvironment using topological data analysis.

NPJ systems biology and applications·2026

Same author

Site-dependent Treg cell transcriptional reprogramming in a metastatic colorectal cancer model holds prognostic significance.

Cancer letters·2026

Same author

Treatments for metastatic non-small cell lung cancer: a pathways pilot with systematic review, evidence synthesis and economic model.

Health technology assessment (Winchester, England)·2026

Same author

TAR syndrome causal gene RBM8A is critical for embryonic bone development and proper Hedgehog signaling.

Research square·2026

Same author

TAR syndrome causal gene <i>RBM8A</i> is critical for embryonic bone development and proper Hedgehog signaling.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Subventricular zone cell migration: lessons from quantitative two-photon microscopy.

Rachel James¹, Yongsoo Kim, Philip E Hockberger

¹Department of Physiology, Anatomy and Genetics, University of Oxford Oxford, UK.

Frontiers in Neuroscience

|April 8, 2011

Summary

This summary is machine-generated.

Adult neuroblasts migrate in the brain

Keywords:

migration multiphoton neuroblast subependymal layer subependymal zone

More Related Videos

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

Published on: December 11, 2010

Related Experiment Videos

Last Updated: Jun 3, 2026

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

Published on: December 11, 2010

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Adult neuroblasts originate in the subventricular zone (SVZ).
These cells migrate via the rostral migratory stream (RMS) to the olfactory bulbs.
They differentiate into interneurons, integrating into brain circuitry.

Purpose of the Study:

To investigate the dynamic parameters of neuroblast migration in the adult SVZ and RMS.
To uncover novel aspects of SVZ neuroblast migration using advanced imaging techniques.

Main Methods:

Utilized two-photon time-lapse microscopy for analyzing migration in acute brain slices.
Analyzed 3D image stacks over time to capture dynamic cellular behaviors.
Examined migration from population to single-cell levels within the SVZ and RMS.

Main Results:

Discovered that neuroblast chains remain stable during migration.
Observed that cells can be immotile for extended periods.
Found that cell morphology does not always correlate with motility.
Identified local exploratory motility and distinctive turning angles in migrating neuroblasts.
Documented dorsoventral migration occurring throughout the striatal SVZ.

Conclusions:

SVZ neuroblast migration is a complex process with previously unrecognized dynamic features.
Two-photon microscopy provides valuable insights into the behavior of migrating neuroblasts.
Further research using current and emerging techniques is needed to address remaining questions in SVZ neuroblast migration.