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Effects of donepezil on behavioral manifestations of thalamic infarction: a single-case observation

Rodrigo Riveros¹, Hughes Chabriat, Rodrigo Flores

¹Cognitive Neurology and Dementia Unit, Neurology Service, El Salvador Hospital Santiago, Chile.

Frontiers in Neurology

|April 8, 2011

Abstract

Objective:

To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus.

Background:

Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions.

Method:

The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study.

Results:

Significant behavioral modifications related to improved performances in executive functions were observed with the treatment.

Conclusion:

The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions.

Keywords:

donepezil dysexecutive syndrome stroke thalamus vascular dementia vascular subcortical cognitive impairment

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