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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Related Experiment Video

Updated: Jun 3, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

Colon cancer stem cells.

Feras J Abdul Khalek, G Ian Gallicano, Lopa Mishra

    Gastrointestinal Cancer Research : GCR
    |April 8, 2011
    PubMed
    Summary

    Colorectal cancer (CRC) research highlights the cancer stem cell (CSC) model, suggesting tumors arise from self-renewing cells. Understanding CSCs in CRC may improve treatment resistance and patient outcomes.

    Area of Science:

    • Oncology
    • Stem Cell Biology
    • Molecular Biology

    Background:

    • Colorectal cancer (CRC) is a leading cause of cancer-related death in the US.
    • Over 80% of sporadic colon tumors exhibit mutations in Wnt and TGFβ signaling pathways.
    • The cancer stem cell (CSC) model is an emerging paradigm in oncology.

    Purpose of the Study:

    • To explore the role of stem cell biology in colorectal cancer development.
    • To understand mechanisms of tumor initiation and therapy resistance driven by CSCs.
    • To identify potential therapeutic strategies targeting CSCs in CRC.

    Main Methods:

    • Analysis of CSC biomarkers using flow cytometry.
    • Investigation of aberrant signaling pathways (Wnt, TGFβ) in CSCs.

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    Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
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    Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

    Published on: January 3, 2015

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    Published on: July 22, 2020

    Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
    11:28

    Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

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    Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
    08:39

    Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

    Published on: January 3, 2015

  • Assessment of CSC behavior in spheroid culture and in vivo models.

    • Main Results:

    • Growing evidence supports the CSC model's role in CRC initiation and growth.
    • CSCs exhibit self-renewal and multi- or pluripotency.
    • Abnormal signaling pathways and symmetric division are characteristic of CSCs.

    Conclusions:

    • The CSC model provides critical insights into colorectal cancer pathogenesis.
    • Targeting CSCs holds promise for overcoming therapy resistance in CRC.
    • Further research into CSC biology is crucial for improving patient outcomes.