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Related Experiment Video

Updated: Jun 3, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Controlling flow in microfluidic channels with a manually actuated pin valve.

Marie-Elena Brett1, Shuping Zhao, Jonathan L Stoia

  • 1Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Biomedical Microdevices
|April 8, 2011
PubMed
Summary

A simple push pin valve with a polydimethylsiloxane (PDMS) tip offers on/off control for microfluidic channels. This low-cost, passive valve design is easy to fabricate and use for fluid flow regulation.

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Area of Science:

  • * Engineering
  • * Materials Science
  • * Biotechnology

Background:

  • * Microfluidic devices require precise control over fluid flow.
  • * Existing methods for flow control can be complex or require external power sources.
  • * There is a need for simple, low-cost, and passive flow control solutions in microfluidics.

Purpose of the Study:

  • * To develop and validate a simple, manually operated valve for microfluidic systems.
  • * To assess the performance and limitations of the push pin valve design.
  • * To evaluate the valve's suitability for controlling fluid introduction in microfluidic devices.

Main Methods:

  • * Fabrication of a push pin valve using a metal tube with a polydimethylsiloxane (PDMS) tip.
  • * Integration of the valve into microfluidic channels for flow obstruction.

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Last Updated: Jun 3, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Published on: October 1, 2007

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  • * Validation using a pressure transducer and fluorescent dye to measure breakthrough pressure over multiple cycles.

    • Main Results:

    • * The push pin valve achieved on/off control of fluid flow without external power.
    • * The median breakthrough pressure in the first cycle was 8.8 psi (range: 2.7–17.5 psi).
    • * Subsequent cycles showed reduced pressure tolerance, suggesting optimal use for initial fluid introduction.

    Conclusions:

    • * The developed push pin valve offers a simple, low-cost, and effective method for microfluidic flow control.
    • * The valve design has minimal dead volume and is easy to fabricate and operate.
    • * This technique is suitable for various microfluidic applications, particularly for controlling initial fluid introduction.