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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

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Published on: July 16, 2017

The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods.

Margaret J Gabanyi1, Paul D Adams, Konstantin Arnold

  • 1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Journal of Structural and Functional Genomics
|April 8, 2011
PubMed
Summary

The Structural Biology Knowledgebase (SBKB) is a web resource that transforms structural genomics data into biological knowledge. It enables researchers to access protein structures, annotations, and experimental data for understanding life and disease.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Genomics

Background:

  • Structural genomics and structural biology efforts generate vast amounts of data.
  • This data needs to be translated into accessible knowledge for the broader biological community.
  • Understanding living systems and disease relies on detailed protein structure information.

Purpose of the Study:

  • To present the Structural Biology Knowledgebase (SBKB) as an open web resource.
  • To demonstrate how SBKB can be utilized to facilitate biological research.
  • To showcase the integrated features and resources available through SBKB.

Main Methods:

  • Utilizing protein sequence or Protein Data Bank (PDB) structure ID searches.
  • Performing text searches for publications and technology reports.
  • Describing web tools for community-driven protein structure requests.

Main Results:

  • SBKB provides access to PDB structures, annotations, homology models, and experimental protocols.
  • Users can order DNA clones from the PSI:Biology-Materials Repository.
  • Text searches yield PSI high-throughput research reports.
  • SBKB includes a research library, editorials, news, and an events calendar.

Conclusions:

  • SBKB effectively transforms structural biology data into actionable knowledge.
  • The resource empowers researchers with integrated tools and information for biological discovery.
  • SBKB fosters a broader understanding of structural genomics and its impact on biomedical research.