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[A clinical study on changes of EGF in serum before and after endoscopic surgery in patients with chronic sinusitis
1Department of Otolaryngology, the Centrol Hospital of Xiangyang, Xiangyang, 441021, China. wangpju@sohu.com
Objective:
To evaluate the changes of epidermal growth factor (EGF) in serum before and after endoscopic surgery in patients with chronic sinusitis, and then to explore its clinical significance.
Method:
Serum was collected before and after operation and EGF concentrations were measured by the radioimmunoassay at different times.
Result:
EGF levels in patients with chronic sinusitis (1.24 +/- 0.41) microg/L were higher than that in control group (0.92 +/- 0.23) microg/L, but there were no significantly difference between them (P > 0.05). The concentrations of EGF were reduced after surgery, and the lowest were evaluated after 4 weeks. Significant difference of EGF concentrations were found between before and 4 weeks after operation (P < 0.01). The concentration of EGF were raised 6 weeks after surgery, and returned to normal after 8 weeks.
Conclusion:
The changes of EGF in serum before and after endoscopic surgery may relate with the epithelization process of sinus mucosa after endoscopic surgery.
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