Tissue engineering with recombinant human platelet-derived growth factor BB for implant site development
Marc L Nevins1, Mark A Reynolds
1Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995)
|April 9, 2011
Summary
Platelet-derived growth factor-BB (PDGF-BB) shows promise when used off-label with bone allografts for dental implant site development. Clinical cases demonstrate successful outcomes in ridge preservation and augmentation procedures.
Area of Science:
- Dentistry
- Regenerative Medicine
- Biomaterials
Background:
- Platelet-derived growth factor-BB (PDGF-BB) is FDA-approved for periodontal regeneration with beta-TCP scaffolds.
- Clinical interest exists in combining PDGF-BB with bone allografts for enhanced bone regeneration.
- This article explores the off-label use of PDGF-BB with bone allografts in various implant site development scenarios.
Observation:
- Case reports detail the use of rhPDGF-BB (0.5 ml of 0.3 mg/ml) with particulate bone allografts (FDBA or DFDBA).
- Procedures included ridge preservation for extraction sockets (with and without alveolar wall defects, minimally invasive techniques), lateral ridge augmentation, and sinus augmentation.
- Clinical, radiographic, and histologic data were collected to evaluate treatment outcomes.
Findings:
- The combination of rhPDGF-BB and bone allografts was utilized off-label, deemed consistent with good clinical practice.
- Selected case reports illustrate positive treatment outcomes for diverse alveolar augmentation procedures.
- The presented cases highlight the potential of this combined strategy in implant dentistry.
Implications:
- The findings suggest that rhPDGF-BB combined with bone allografts can be a viable strategy for implant site development.
- Further controlled clinical trials are required to definitively establish the efficacy of rhPDGF-BB with various mammalian bone graft scaffolds.
- This research opens avenues for exploring novel applications of growth factors in bone regeneration for dental implants.
