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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: Jun 3, 2026

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Antibodies in oncology.

Vinochani Pillay1, Hui K Gan, Andrew M Scott

  • 1Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria 3084, Australia.

New Biotechnology
|April 9, 2011
PubMed
Summary

Monoclonal antibodies (mAbs) are revolutionizing cancer treatment by targeting tumors through various mechanisms. This review covers approved and developing anti-cancer mAbs, their targets, and action modes.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Monoclonal antibodies (mAbs) represent a significant advancement in cancer therapy, approved for numerous human malignancies.
  • Their therapeutic potential is realized through diverse mechanisms, including signal inhibition, apoptosis induction, and immune system enhancement.

Purpose of the Study:

  • To provide a comprehensive overview of therapeutic monoclonal antibodies (mAbs) in clinical oncology.
  • To discuss the mechanisms of action and antigen targets of anti-cancer mAbs.

Main Methods:

  • Review of approved and clinically developing monoclonal antibodies (mAbs) for cancer treatment.
  • Analysis of the diverse functional mechanisms employed by these therapeutic antibodies.
  • Identification of key molecular targets recognized by anti-cancer mAbs.

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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Main Results:

  • Monoclonal antibodies (mAbs) are a major class of therapeutic agents in oncology.
  • These antibodies utilize multiple mechanisms to combat cancer, including direct tumor cell killing and immune modulation.
  • A growing number of mAbs are in clinical trials, reflecting advances in understanding cancer biology.

Conclusions:

  • Monoclonal antibodies (mAbs) have transformed cancer treatment paradigms.
  • Understanding their mechanisms and targets is crucial for developing effective anti-cancer therapies.
  • The field continues to evolve with new mAb constructs and targets emerging in clinical development.