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Related Experiment Video

Updated: Jun 3, 2026

Establishment of an Embryo Implantation Model In Vitro

Establishment of an Embryo Implantation Model In Vitro

Published on: June 21, 2024

Hormone-induced delayed ovulation affects early embryonic development.

Ann-Kathrin Bittner¹, Bernhard Horsthemke, Elke Winterhager

¹Institute of Molecular Biology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Fertility and Sterility

|April 9, 2011

Summary

This summary is machine-generated.

Delayed ovulation in mice, induced by cetrorelix, negatively impacted embryonic development. This resulted in more resorption sites and lower embryonic weight, suggesting potential fertility issues during assisted reproductive technology (ART).

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Published on: April 7, 2023

Area of Science:

Reproductive Biology
Developmental Biology
Assisted Reproductive Technology (ART)

Background:

Oocyte development can be delayed during human assisted reproductive technology (ART).
Understanding the impact of delayed ovulation on embryonic development is crucial for improving ART outcomes.

Purpose of the Study:

To investigate the effects of delayed ovulation on embryonic development in a mouse model.
To analyze how intrafollicular oocyte maturation delays influence fertility and offspring development.

Main Methods:

Experimental study using female C57Bl/6 mice.
Cetrorelix (GnRH-antagonist) was administered with follicle stimulation to delay ovulation.
Ovulation was induced with hCG; controls received stimulation without ovulation delay.
Ovarian assessments (follicles, corpora lutea) and embryonic development parameters (weight, resorption sites) were evaluated.

Main Results:

Cetrorelix effectively inhibited ovulation, evidenced by increased tertiary follicles and reduced follicle rupture/corpora lutea.
Delayed ovulation significantly increased the number of resorption sites.
A significant decrease in embryonic weight was observed in the delayed ovulation group.

Conclusions:

Preovulatory oocyte overripeness, induced by delayed ovulation, adversely affects fertility.
These findings suggest that oocyte aging during ART may compromise embryonic development and successful implantation.