Related Experiment Video
Updated: Jun 3, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis and hybridization data of oligonucleotide analogs with triazole internucleotide linkages, potential
Anna Varizhuk1, Alexandr Chizhov, Vladimir Florentiev
1Engelhardt Institute of Molecular Biology, Vavilov str., 32, 119991 Moscow, Russia.
Abstract:
Triazolyl-functionalized oligonucleotide (ON) analogs have received much attention as potential antitumor and antiviral agents. The most promising of such analogs are those exhibiting high binding affinity toward native DNA/RNA, since they may prove to be efficient antisense or siRNA agents. To date, relatively few ON analogs with triazole internucleotide linkages have been described. In this paper, we report an improved synthesis of a modified dinucleoside phosphoramidite and hybridization data of ON analogs with four-bond triazole internucleotide linkages. We believe these data are essential for comprehensive analysis of the relation between the length of triazole internucleotide linkages and duplex stability.
More Related Videos
10:29Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
11:37Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
Published on: July 28, 2017
Related Concept Videos
Antiviral Nucleoside Inhibitors
Inhibitors of Bacterial DNA Synthesis
DNA Base Pairing
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Inhibitors of Viral Protein Synthesis