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Related Concept Videos

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Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
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Related Experiment Video

Updated: Jun 3, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Post-splenectomy and hyposplenic states.

Antonio Di Sabatino1, Rita Carsetti, Gino Roberto Corazza

  • 1First Department of Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, Italy.

Lancet (London, England)
|April 9, 2011
PubMed
Summary

The spleen is vital for immune function. Impaired splenic function (hyplenism) or absence (asplenia) increases infection risk, necessitating preventative strategies like vaccination and antibiotics.

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Last Updated: Jun 3, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
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Published on: June 11, 2019

Area of Science:

  • Immunology
  • Hematology

Background:

  • The spleen plays a critical role in immune homeostasis by bridging innate and adaptive immunity.
  • Hyposplenism (impaired splenic function) and asplenia (absent spleen) are conditions that compromise immune defenses.
  • These conditions, often acquired, predispose individuals to severe infections, particularly from encapsulated bacteria.

Purpose of the Study:

  • To review the clinical and diagnostic aspects of splenic dysfunction.
  • To highlight new perspectives in preventing overwhelming post-splenectomy infections.
  • To emphasize the importance of preventative measures for patients with hyposplenism or asplenia.

Main Methods:

  • Critical assessment of clinical and diagnostic features of splenic dysfunction.
  • Review of current literature on infectious complications associated with hyposplenism and asplenia.
  • Exploration of novel strategies for infection prevention in asplenic and hyposplenic individuals.

Main Results:

  • Hyposplenism and asplenia significantly increase the risk of overwhelming infections.
  • Infections in these patients are often caused by encapsulated bacteria, characterized by high mortality and rapid progression.
  • Current management strategies prioritize prevention through vaccination and antibiotic prophylaxis.

Conclusions:

  • Splenic dysfunction necessitates vigilant management focused on preventing severe infections.
  • Vaccination and antibiotic prophylaxis are cornerstones in managing patients with hyposplenism or asplenia.
  • Further research into novel preventative approaches is crucial for improving outcomes in these vulnerable populations.