Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat
1Department of Surgery, Second Hospital of HeBei Medical University, School of Basic Medical Sciences, HeBei Medical University, Shijiazhuang 050000, PR China. biwei8115@sohu.com
European Journal of Medicinal Chemistry
|April 9, 2011
Abstract:
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.
