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Magnetic susceptibility (MA) affects peripheral nerve MRN T2 signal, but does not cause false positives. Neuropathic lesions are distinguishable from MA-induced T2 signal changes in MRN.

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Area of Science:

  • Medical Imaging
  • Neuroscience
  • Biophysics

Background:

  • Magnetic Resonance Neurography (MRN) is an emerging technique for diagnosing peripheral nerve disorders.
  • The impact of magnetic susceptibility (MA) on intraneural T2 signal in MRN requires clarification to prevent false-positive findings.

Purpose of the Study:

  • To investigate the influence of MA on intraneural T2 signal in healthy subjects.
  • To determine if MA-induced T2 signal changes can be distinguished from neuropathic lesions.

Main Methods:

  • MRN of the sciatic nerve was performed at 3T in 25 healthy subjects.
  • Apparent T2 (T2(app)) was calculated at various angles (0°–55°) relative to B0 using a DE-TSE sequence.
  • Intraneural contrast-to-noise ratios (CNRs) were compared between healthy subjects and 14 patients with neuropathic lesions using a TIRM sequence.

Main Results:

  • T2(app) significantly increased with MA angle in healthy subjects (74.5 ms at 0° to 104.0 ms at 55°).
  • Intraneural CNR increased with MA, but remained substantially lower in healthy subjects compared to patients even at maximum MA (55°).

Conclusions:

  • Neuropathic lesions are clearly distinguishable from MA-induced increases in intraneural T2 signal.
  • False-positive determination of neuropathic lesions due to MA is unlikely, even at maximum MA (55°).