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Updated: Jun 3, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Genetic associations of autopsy-confirmed vascular dementia subtypes
Emma L Jones1, Rajesh N Kalaria, Sally I Sharp
1Wolfson CARD, King's College London, London, UK. emma.3.jones@kcl.ac.uk
Background/Aims:
Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease.
Methods:
Samples were genotyped for APOE, MTHFR and ICAM. Aβ levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD.
Results:
Associations were found between the APOE-ε4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher Aβ1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity.
Conclusions:
The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates.
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