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Related Experiment Video

Updated: Jun 3, 2026

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

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Steroid therapy for problematic proliferating haemangioma.

Beryl H Tan¹, Philip H Leadbitter, Neil H Aburn

¹Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital, High Street, Private Bag 31-907, Lower Hutt, New Zealand.

The New Zealand Medical Journal

|April 9, 2011

Summary

Systemic and intralesional steroid therapies effectively treat problematic proliferating haemangiomas with manageable side effects. While effective, propranolol may become the preferred first-line treatment for these vascular anomalies.

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Area of Science:

Vascular Anomalies
Pediatric Dermatology
Pharmacology

Background:

Proliferating haemangiomas can cause significant complications requiring intervention.
Steroid therapy has been a common treatment modality for these lesions.

Purpose of the Study:

To evaluate the safety and effectiveness of systemic and intralesional steroid therapy for problematic proliferating haemangioma.

Main Methods:

A retrospective review of 233 patients with haemangioma.
Analysis of 24 patients treated with intralesional triamcinolone or oral prednisolone.
Recording of treatment indications, response, side effects, and need for further intervention.

Main Results:

Intralesional triamcinolone showed accelerated regression in 80% of patients with no complications.
Oral prednisolone resulted in an 89% response rate, with accelerated regression in 53% of patients.
Short-term side effects included growth retardation (resolved post-treatment) and mild Cushingoid features.

Conclusions:

Both intralesional and systemic steroids are safe and effective for problematic proliferating haemangioma.
Systemic steroid therapy presents few short-term side effects.
Multidisciplinary management is crucial, and propranolol may emerge as a preferred first-line treatment.