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Related Experiment Video

Updated: Jun 2, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Acral Lentigines, Is it a Paraneoplastic Syndrome?

Saad Al Mohizea¹, Amal Al-Balbeesi

¹Department of Dermatology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

International Journal of Health Sciences

|April 9, 2011

Summary

A 34-year-old man developed brown spots on his skin after a non-Hodgkin

Area of Science:

Dermatology
Oncology
Immunology

Background:

A 34-year-old gentleman with a history of Evan's syndrome and membranoproliferative glomerulonephritis, treated with mycophenolate mofetil (MMF), was diagnosed with non-Hodgkin's lymphoma.
He presented with multiple brown spots on the palms, soles, and scalp, appearing three months prior to his lymphoma diagnosis.

Observation:

Clinical examination revealed multiple brownish macules distributed across the palms, soles, and scalp.
A biopsy of a palmar lesion demonstrated basal cell layer pigmentation and an increase in melanocytes.

Findings:

The observed skin lesions, characterized as lentigines, are strongly suspected to be induced by immunosuppression.
The immunosuppression was a consequence of the treatment for non-Hodgkin's lymphoma.

Keywords:

acral lentigines malignancy paraneoplastic syndromes

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Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Implications:

This case highlights a potential cutaneous side effect of immunosuppressive therapy in patients with hematologic malignancies.
Further research may elucidate the specific mechanisms linking immunosuppression, non-Hodgkin's lymphoma, and drug treatments to the development of drug-induced lentigines.