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Updated: Jun 2, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Extended venous thromboembolism prophylaxis for high-risk patients undergoing surgery for malignancy
1Cancer Treatment Centers of America, Eastern Regional Medical Center, Philadelphia, Pa., USA.
Background:
In surgical patients with known malignancy, the odds ratio for an episode of a venous thromboembolism is approximately 6.5 compared to a group of patients without malignancy undergoing the same procedure [Heit et al.: Arch Intern Med 2000;160:809-815].
Case Report:
We present a case of a 46-year-old Caucasian male with a history of adenocarcinoma of the rectum. The patient received neoadjuvant treatment prior to low anterior resection with diverting colostomy. He received short-term prophylaxis for venous thrombosis, but unfortunately developed a blood clot in a lower extremity several weeks after surgery.
Conclusion:
There is a well-defined role in carefully selected patients for the use of extended prophylaxis to prevent venous thromboembolic complications following cancer surgery.
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