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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

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Published on: July 20, 2019

TNF-alpha polymorphisms and breast cancer.

Yu Yang¹, Rennan Feng, Sheng Bi

¹Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086, Harbin, People's Republic of China.

Breast Cancer Research and Treatment

|April 9, 2011

Summary

This meta-analysis found no significant link between Tumor Necrosis Factor-alpha (TNF-α) gene polymorphisms and overall breast cancer risk. However, a negative association was observed between TNF-α-308 polymorphism and breast cancer in Caucasian populations.

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Published on: January 18, 2017

Area of Science:

Genetics
Oncology
Immunology

Background:

Tumor Necrosis Factor-alpha (TNF-α) is a pro-inflammatory cytokine implicated in cancer development.
TNF-α gene polymorphisms are known to affect cancer risk, but their association with breast cancer (BC) is debated.

Purpose of the Study:

To conduct a meta-analysis for precise estimation of the association between TNF-α polymorphisms (-238, -308, -857, -863, -1031, -1210) and breast cancer risk.

Main Methods:

Systematic electronic database searches were performed for relevant studies published up to March 2011.
Meta-analysis utilized Odds Ratios (OR) with 95% Confidence Intervals (CI) in fixed- and random-effect models.
Included 17 studies encompassing 44,442 BC patients and 49,926 controls.

Main Results:

No significant association was found between TNF-α-308 polymorphism and overall or Asian BC risk.
A negative association was observed between TNF-α-308 polymorphism and BC risk in Caucasian populations.
No significant associations were detected for TNF-α-238, -857, -863, -1031, or -1210 polymorphisms with BC risk in any population subgroup.

Conclusions:

The studied TNF-α gene polymorphisms (-308, -238, -857, -863, -1031, -1210) are not significantly associated with overall breast cancer risk.
A potential negative association exists between TNF-α-308 polymorphism and breast cancer risk specifically within Caucasian populations.