Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer.

Chemical science·2022
Same author

<i>In vitro</i> cell culture models for ultrasound treatments using collagen-based scaffolds.

MethodsX·2022
Same author

All-natural gelatin-based bioorthogonal catalysts for efficient eradication of bacterial biofilms.

Chemical science·2022
Same author

Enhanced Design of Gold Catalysts for Bioorthogonal Polyzymes.

Materials (Basel, Switzerland)·2022
Same author

An Extracellular Matrix-like Surface for Zn Alloy to Enhance Bone Regeneration.

ACS applied materials & interfaces·2022
Same author

Porous Polymerized High Internal Phase Emulsions Prepared Using Proteins and Essential Oils for Antimicrobial Applications.

Langmuir : the ACS journal of surfaces and colloids·2022
Same journal

Synergistic Impact of Turkey Red Oil and Sodium Oleate on the Separation of Dolomite from Apatite.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Metal Substrate-Dependent Tribological Performance of Environmentally Acceptable Ester-PAO Lubricant Blends.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

From Waste to Water Remediation: Fly Ash-Derived Hectorite for Dye and Heavy Metal Removal.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Mechanism of the Cholesterol-dependent Anchoring and Conformation of LPP-scFv on the PEGylated Liposome Surface.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Visualizing Cooperative Adsorption of an Enzyme Mixture at an Air-Liquid Interface.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Unraveling Nanoplastics-Enzyme Interactions: Physicochemical, Structural, Functional, and Cell Biological Characterization of α-Amylase-Nanoplastics Complexes.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Nano meets biology: structure and function at the nanoparticle interface.

Daniel F Moyano1, Vincent M Rotello

  • 1Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 12, 2011
PubMed
Summary
This summary is machine-generated.

Monolayer design helps understand and control how nanoparticles interact with biomolecules and cells. This research uses engineered nanoparticles to probe critical interfaces in biomedicine and environmental science.

More Related Videos

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
10:50

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

Synthesis of Persistent Luminescent Nanoparticles for Rewritable Displays and Illumination Applications
07:12

Synthesis of Persistent Luminescent Nanoparticles for Rewritable Displays and Illumination Applications

Published on: September 13, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
10:50

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions

Published on: April 3, 2014

Synthesis of Persistent Luminescent Nanoparticles for Rewritable Displays and Illumination Applications
07:12

Synthesis of Persistent Luminescent Nanoparticles for Rewritable Displays and Illumination Applications

Published on: September 13, 2024

Area of Science:

  • Biomedical science
  • Environmental science
  • Nanotechnology

Background:

  • Understanding nanomaterial interactions with biological systems is crucial for biomedicine and environmental science.
  • Engineered nanoparticles are valuable tools for studying these complex interfaces.
  • Recent research focuses on controlling these interactions through precise design.

Purpose of the Study:

  • To summarize a Langmuir lecture on using monolayer design for nanoparticle interaction studies.
  • To elucidate methods for understanding and controlling nanoparticle interactions with biomolecules.
  • To explore the application of engineered nanoparticles in probing biosystem interfaces.

Main Methods:

  • Utilizing monolayer design principles.
  • Employing engineered nanoparticles as probes.
  • Analyzing interactions at the biomolecule-nanoparticle interface.

Main Results:

  • Demonstrated the efficacy of monolayer design in controlling nanoparticle behavior.
  • Provided insights into the mechanisms of nanoparticle-biomolecule interactions.
  • Highlighted the potential of engineered nanoparticles in biosystem research.

Conclusions:

  • Monolayer design is a powerful strategy for managing nanoparticle-biosystem interactions.
  • Engineered nanoparticles offer unique capabilities for fundamental research.
  • This approach advances both biomedical and environmental applications of nanotechnology.