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Updated: Jun 2, 2026

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
Published on: October 10, 2016
Dithiolate-appended iridium(III) complex with dual functions of reducing and capping agent for the design of
Gihane Nasr1, Audrey Guerlin, Frédéric Dumur
1Institut Lavoisier de Versailles, Université de Versailles Saint-Quentin en Yvelines, UMR 8180 CNRS, 78035 Versailles, France.
Abstract:
The unprecedented combined reduction of chloroauric acid and capping of the resulting gold nanoparticles in the absence of an external reducing agent are demonstrated using a novel heteroleptic Ir(III) complex incorporating a 4,5-diazafluorenedithiolate ligand. The reduction process in basic medium results from a cascade mechanism involving oxidation of the ligand, reduction of the gold salt, and stabilization and functionalization of the gold nanoparticles.
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