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General features of persistent virus infections.

C A Mims

    Postgraduate Medical Journal
    |September 1, 1978
    PubMed
    Summary

    Persistent viruses utilize specific body sites like glands and germ cells for survival and transmission. Targeting lymphoreticular tissues may impair immune responses, aiding viral persistence and reactivation.

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    Epidemiology and infection·1991

    Area of Science:

    • Virology
    • Immunology
    • Cell Biology

    Background:

    • Persistent viral infections pose significant challenges to host health.
    • Understanding viral strategies for long-term survival is crucial for developing effective treatments.

    Purpose of the Study:

    • To explore the viral perspective on persistent infections.
    • To identify key anatomical sites and host-virus interactions that facilitate viral persistence.

    Main Methods:

    • Review and interpretation of existing virological and immunological data.
    • Analysis of viral tropism and persistence mechanisms across different bodily sites.

    Main Results:

    • Glands and body surfaces offer topographical protection and facilitate shedding.
    • Germ cells enable vertical transmission, while the central nervous system is a 'dead end'.
    • Lymphoreticular tissue infection may impair immune response, favoring persistence.

    Conclusions:

    • Viral persistence is facilitated by specific anatomical locations and immune evasion strategies.
    • Virus transformation and DNA integration are key for long-term persistence and reactivation.
    • Papovaviruses, adenoviruses, and oncornaviruses exemplify these persistence mechanisms.

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