Exploring modifiable risk factors for wheezing in African American premature infants

Jada L Brooks1, Diane Holditch-Davis, Lawrence R Landerman

  • 1School of Nursing, Duke University, Durham, NC 27710, USA.

Insights

Positive maternal attention and public assistance were linked to increased wheezing risk in premature African American infants. Other factors like obesity and secondhand smoke showed no significant association with early wheezing development.

Area of Science:

  • Pediatrics
  • Neonatal Care
  • Respiratory Health

Background:

  • Wheezing is a common respiratory symptom in infants, particularly premature infants.
  • Understanding risk factors for early wheezing is crucial for timely intervention.

Purpose of the Study:

  • To investigate the relationship between infant obesity, secondhand smoke exposure, parenting styles, and the early development of wheezing in African American premature infants.
  • To identify key predictors of wheezing in this vulnerable population.

Main Methods:

  • Secondary analysis of data from a larger nursing support intervention study.
  • Involved 168 African American premature infants and their mothers from two regional perinatal centers.
  • Wheezing data collected via maternal report at 2, 6, 12, 18, and 24 months corrected age.

Main Results:

  • Medically significant wheezing increased from 12% at 2 months to 24% at 24 months corrected age.
  • Infants receiving more positive maternal attention showed a slightly higher probability of developing wheezing.
  • Infants of mothers receiving public assistance had an increased probability of wheezing.

Conclusions:

  • Positive maternal attention and maternal public assistance are associated with an increased likelihood of wheezing in African American premature infants.
  • Modifiable risk factors like obesity and secondhand smoke were not strongly related to wheezing development.
  • Intervention should focus on early identification and treatment of wheezing and asthma-related symptoms.
Abstract

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.