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Published on: August 7, 2017
Exploring modifiable risk factors for wheezing in African American premature infants
Jada L Brooks1, Diane Holditch-Davis, Lawrence R Landerman
1School of Nursing, Duke University, Durham, NC 27710, USA.
Insights
Positive maternal attention and public assistance were linked to increased wheezing risk in premature African American infants. Other factors like obesity and secondhand smoke showed no significant association with early wheezing development.
Area of Science:
- Pediatrics
- Neonatal Care
- Respiratory Health
Background:
- Wheezing is a common respiratory symptom in infants, particularly premature infants.
- Understanding risk factors for early wheezing is crucial for timely intervention.
Purpose of the Study:
- To investigate the relationship between infant obesity, secondhand smoke exposure, parenting styles, and the early development of wheezing in African American premature infants.
- To identify key predictors of wheezing in this vulnerable population.
Main Methods:
- Secondary analysis of data from a larger nursing support intervention study.
- Involved 168 African American premature infants and their mothers from two regional perinatal centers.
- Wheezing data collected via maternal report at 2, 6, 12, 18, and 24 months corrected age.
Main Results:
- Medically significant wheezing increased from 12% at 2 months to 24% at 24 months corrected age.
- Infants receiving more positive maternal attention showed a slightly higher probability of developing wheezing.
- Infants of mothers receiving public assistance had an increased probability of wheezing.
Conclusions:
- Positive maternal attention and maternal public assistance are associated with an increased likelihood of wheezing in African American premature infants.
- Modifiable risk factors like obesity and secondhand smoke were not strongly related to wheezing development.
- Intervention should focus on early identification and treatment of wheezing and asthma-related symptoms.
Objective:
To examine the degree to which obesity during infancy, consistent exposure to secondhand smoke, and parenting (positive attention, maternal involvement, and negative control) were related to early development of wheezing in a cohort of African American premature infants at 2, 6, 12, 18, and 24 months corrected age.
Design:
Secondary analysis of a subset of variables from a larger nursing support intervention study.
Setting:
Two regional perinatal centers in the southeastern United States.
Participants:
One hundred and sixty-eight African American premature infants (70 boys, 98 girls) who weighed less than 1,750 g or required mechanical ventilation and their mothers.
Methods:
The presence of wheezing was obtained from maternal report at 2, 6, 12, 18, and 24 months. Infants were considered to have medically significant wheezing if they were using bronchodilators or pulmonary anti-inflammatory medications.
Results:
The percentage of infants who had medically significant wheezing increased from 12% at 2 months to 24% at 24 months corrected age. Infants who received more positive attention from their mothers had a slightly higher increase in the probability of developing wheezing over time. Infants of mothers who received public assistance had an increased probability of wheezing. Consistent exposure to secondhand smoke, obesity during infancy, maternal negative control, and maternal involvement were not related to the development of wheezing.
Conclusion:
These findings suggest that the likelihood of developing wheezing in African American premature infants is associated with receiving more positive attention from their mothers and having mothers who receive public assistance. Because modifiable risk factors were not highly related to wheezing, intervention efforts need to focus on early identification and treatment of wheezing and asthma-related symptoms.
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