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Related Experiment Videos

Age, steroids and bone mineral content.

S Rozenberg1, H Ham, D Bosson

  • 1Interdisciplinary Group on Osteoporosis, Free University of Brussels (VUB-ULB), St Peter's Hospital, Belgium.

Maturitas
|June 1, 1990
PubMed
Summary

Bone mineral content (BMC) is linked to specific steroid hormones. Oestradiol (E2) influences lumbar bone, while dehydroepiandrosterone sulphate (DHEA-S) affects cortical bone, independent of age.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Gerontology

Background:

  • Bone mineral content (BMC) is crucial for skeletal health, and its regulation by hormones is complex.
  • Steroid hormones, including dehydroepiandrosterone sulphate (DHEA-S) and oestradiol (E2), are known to play roles in bone metabolism.

Purpose of the Study:

  • To investigate the correlations between BMC, age, and serum levels of various steroid hormones.
  • To determine which specific hormones are associated with BMC at different skeletal sites.

Main Methods:

  • Serum levels of steroid hormones and BMC were measured.
  • Statistical analyses including partial correlations and stepwise multiple regression were employed.
  • Adjustments for age were made to assess hormone-BMC relationships.

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Main Results:

  • Dehydroepiandrosterone sulphate (DHEA-S), oestradiol (E2), and delta-4-androstenedione (A) showed correlations with BMC.
  • Significant partial correlations, after age adjustment, were found between E2 and BMC at the L2-L4 lumbar site, and between DHEA-S and BMC at the midradius site.
  • Multiple regression identified E2 as a predictor for lumbar BMC and DHEA-S for midradius BMC.

Conclusions:

  • Different steroid hormones are associated with BMC at distinct skeletal locations.
  • Oestradiol (E2) is linked to lumbar trabecular bone (L2-L4), while DHEA-S is associated with cortical bone at the midradius.
  • These findings highlight site-specific hormonal influences on bone mineral content.