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Related Experiment Videos

Nystagmus in Down's syndrome.

R S Wagner1, A R Caputo, R D Reynolds

  • 1Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark.

Ophthalmology
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Nystagmus, an involuntary eye movement, is common in Down syndrome. This study found fine rapid horizontal nystagmus and dissociated nystagmus frequently occur in these patients, often without clear ocular causes.

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Down syndrome is associated with various health issues, but the prevalence and types of nystagmus are not well-defined.
  • Ocular abnormalities are common in Down syndrome, yet the specific characteristics of nystagmus remain unclear.

Purpose of the Study:

  • To investigate the incidence and specific characteristics of nystagmus in patients with Down syndrome.
  • To determine if identifiable ocular pathologies correlate with the presence of nystagmus in this population.

Main Methods:

  • A consecutive series of 188 patients with Down syndrome were examined.
  • Ocular examinations were performed to identify and classify nystagmus and associated ocular conditions.

Main Results:

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  • Nystagmus was observed in 56 out of 188 patients (approximately 30%).
  • The most common types were fine rapid horizontal nystagmus (29 patients) and dissociated nystagmus (14 patients).
  • Esotropia was present in 41 patients with nystagmus; however, most patients lacked clear ocular pathology explaining the nystagmus.

Conclusions:

  • Fine rapid horizontal nystagmus, sometimes dissociated, is a frequent finding in individuals with Down syndrome.
  • The etiology of nystagmus in Down syndrome often appears unrelated to clinically recognizable ocular pathology.