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Updated: Jun 2, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi sarcoma of the penis in an HIV-negative patient
Roberto Cecchi1, Michela Troiano, Maurizia Ghilardi
1Department of Dermatology, Pistoia Hospital, Pistoia, Italy. r.cecchi@usl3.toscana.it
Background:
The penis is an unusual site of presentation for Kaposi sarcoma, especially in immunocompetent patients.
Case Presentation:
A 52-year-old human immunodeficiency virus (HIV)-seronegative man presented with a reddish, 8 mm in diameter nodule on the glans penis near the coronal sulcus. Histopathology after excision of the lesion was consistent with Kaposi sarcoma. No other cutaneous or mucosal manifestations were present. After a follow-up period of 2 years, no recurrence was observed.
Conclusion:
This unusual case suggests that Kaposi sarcoma should be considered in the differential diagnosis of macular, papular, and nodular lesions involving the penis.
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