Related Experiment Video
Updated: Jun 2, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism
Wah Chin Boon1, Malcolm K Horne
1Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia. wah.chin.boon@florey.edu.au
Abstract:
Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive disorder and neurological disorder such as Parkinsonism. Therefore, by regulating the expression of the oestrogen-synthesising enzyme, aromatase, we may identify what behaviour is regulated by oestrogen. Inhibition of aromatase either genetically or pharmacologically has been reported to induce sexual behaviour impairment, compulsive behaviour and susceptibility to neurodegeneration.
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Drugs Affecting Neurotransmitter Synthesis
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology
Antidepressant Drugs: MAOIs and Other Agents
Alterations in Muscle Tone lll
