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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Plasmablasts and plasma cells: reconsidering teleost immune system organization

Jianmin Ye1, Ilsa Kaattari, Stephen Kaattari

  • 1Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA.

Developmental and Comparative Immunology
|April 12, 2011
PubMed

Comparative immunologists have expended extensive efforts in the characterization of early fish B cell development; however, analysis of the post-antigen induction stages of antibody secreting cell (ASC) differentiation has been limited. In contrast, work with murine ASCs has resolved the physically and functionally distinct cells known as plasmablasts, the short-lived plasma cells and long-lived plasma cells. Teleost ASCs are now known to also possess comparable subpopulations, which can greatly differ in such basic functions as lifespan, antigen sensitivity, antibody secretion rate, differentiative potential, and distribution within the body. Understanding the mechanisms by which these subpopulations are produced and distributed is essential for both basic understanding in comparative immunology and practical vaccine engineering.

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