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Updated: Jun 2, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Modeling multiple risks during infancy to predict quality of the caregiving environment: contributions of a
Stephanie T Lanza1, Brittany L Rhoades, Mark T Greenberg
1The Pennsylvania State University, State College, PA 16801, USA. SLanza@psu.edu
Insights
Latent class analysis (LCA) effectively models infant risk factors, identifying distinct risk profiles. These profiles better predict caregiving quality compared to traditional methods, especially in diverse populations.
Area of Science:
- Child Development
- Maternal Health
- Statistical Modeling
Background:
- Understanding infant risk factors is crucial for predicting caregiving quality.
- Existing methods may not fully capture the complexity of multiple risk interactions.
- Research in low-income, non-urban settings is vital for equitable child development insights.
Purpose of the Study:
- To compare variable-centered and person-centered methods for modeling infant risk factors.
- To predict caregiving environment quality at six months using early childhood risk indicators.
- To explore these relationships in a population from low-income, non-urban communities.
Main Methods:
- Compared bivariate, multiple regression, cumulative risk index, and latent class analysis (LCA).
- Utilized nine risk factors (demographics, maternal psychosocial) assessed at two months.
- Analyzed data from 1047 infants in Pennsylvania and North Carolina.
Main Results:
- Latent class analysis (LCA) provided a more intuitive summary of risk organization than other methods.
- Identified five distinct risk classes: married low-risk, married low-income, cohabiting multiproblem, single low-income, and single low-income/education.
- LCA revealed variations in caregiving quality prediction across race and site based on family configurations.
Conclusions:
- Person-centered models, like LCA, offer valuable insights into the complex interplay of multiple risk factors.
- LCA enhances understanding of how different combinations of risks impact infant caregiving environments.
- Findings underscore the utility of LCA for nuanced prediction in diverse populations.
Abstract:
The primary goal of this study was to compare several variable-centered and person-centered methods for modeling multiple risk factors during infancy to predict the quality of caregiving environments at six months of age. Nine risk factors related to family demographics and maternal psychosocial risk, assessed when children were two months old, were explored in the understudied population of children born in low-income, non-urban communities in Pennsylvania and North Carolina (N = 1047). These risk factors were (1) single (unpartnered) parent status, (2) marital status, (3) mother's age at first child birth, (4) maternal education, (5) maternal reading ability, (6) poverty status, (7) residential crowding, (8) prenatal smoking exposure, and (9) maternal depression. We compared conclusions drawn using a bivariate approach, multiple regression analysis, the cumulative risk index, and latent class analysis (LCA). The risk classes derived using LCA provided a more intuitive summary of how multiple risks were organized within individuals as compared to the other methods. The five risk classes were: married low-risk; married low-income; cohabiting multiproblem; single low-income; and single low-income/education. The LCA findings illustrated how the association between particular family configurations and the infants' caregiving environment quality varied across race and site. Discussion focuses on the value of person-centered models of analysis to understand complexities of prediction of multiple risk factors.
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