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Related Experiment Videos

Risk factors for gastroschisis.

G Goldbaum1, J Daling, S Milham

  • 1School of Public Health and Community Medicine, University of Washington, Seattle 98195.

Teratology
|October 1, 1990
PubMed
Summary

Gastroschisis, a birth defect, is increasing. Risk factors include maternal smoking, young maternal age, inadequate prenatal care, and birth month. Smoking during pregnancy is a key area for further research.

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Area of Science:

  • Pediatric Surgery
  • Birth Defects Research
  • Epidemiology

Background:

  • Gastroschisis (abdominal wall defect) prevalence at birth has risen.
  • Understanding risk factors is crucial for addressing this increase.

Purpose of the Study:

  • To identify risk factors associated with the increasing prevalence of gastroschisis.
  • To investigate potential causes for the observed rise in gastroschisis cases.

Main Methods:

  • Case-control study comparing 62 infants with gastroschisis to 617 unaffected infants.
  • Analysis of Washington State birth certificates (1984-1987).
  • Simultaneous adjustment for 14 potential risk factors.

Main Results:

  • Infants born in Jan-Mar had higher risk (OR 2.2).
  • Younger mothers (<25 years, especially <20) had higher risk (OR 4.1).
  • Maternal smoking (OR 2.0) and inadequate prenatal care (OR 2.1) were associated with increased risk.

Conclusions:

  • Maternal smoking during pregnancy is a plausible, modifiable risk factor for gastroschisis.
  • Unidentified factors linked to birth month, maternal age, and prenatal care warrant further investigation.
  • Further research on smoking's role is needed to explain the rising gastroschisis prevalence.

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