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Related Experiment Video

Updated: Jun 2, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Retinal oximetry based on nonsimultaneous image acquisition using a conventional fundus camera.

Sun Kwon Kim¹, Dong Myung Kim, Min Hee Suh

¹Biomedical Engineering Department, National University, Seoul, Korea. yggdrasil@melab.snu.ac.kr

IEEE Transactions on Medical Imaging

|April 12, 2011

Summary

A new retinal oximetry method accurately measures oxygen saturation in retinal vessels using a standard fundus camera. This technique shows significant changes in oxygen saturation after breathing 100% oxygen.

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Last Updated: Jun 2, 2026

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Area of Science:

Ophthalmology
Medical Imaging
Physiology

Background:

Retinal oxygen saturation measurement is crucial for diagnosing and monitoring various eye conditions.
Conventional methods for retinal oximetry can be complex or require specialized equipment.

Purpose of the Study:

To develop and evaluate a novel retinal oximetry technique using a conventional fundus camera.
To measure retinal arteriole and venule oxygen saturation (SO(2)) non-invasively.

Main Methods:

Two-wavelength oximetry was employed using sequential fundus camera images acquired with 568 nm and 600 nm filters.
Image registration was performed to correct for eye movements during acquisition.
Retinal SO(2) was measured before and after 100% oxygen inhalation in 11 healthy subjects.

Main Results:

Significant increases in arteriole SO(2) (96.0% to 98.8%) and venule SO(2) (54.0% to 66.7%) were observed after 100% oxygen inhalation (p<0.005).
The method demonstrated good reproducibility with average standard deviations of 2.6% for arterioles and 5.2% for venules.

Conclusions:

Retinal oximetry using a conventional fundus camera is feasible and sensitive to changes in oxygen levels.
This non-invasive technique offers a promising approach for assessing retinal oxygenation in clinical settings.