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Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

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Updated: Jun 2, 2026

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

Published on: January 7, 2020

Human macrophage adhesion on polysaccharide patterned surfaces.

Irene Y Tsai¹, Chin-Chen Kuo, Nancy Tomczyk

¹Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

|April 12, 2011

Summary

This summary is machine-generated.

Researchers developed patterned dextran and hyaluronic acid surfaces to reduce inflammation in medical devices. Macrophages, a type of immune cell, showed significantly less adhesion to hyaluronic acid, indicating anti-inflammatory potential for new biomaterials.

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Area of Science:

Biomaterials Science
Surface Chemistry
Immunology

Background:

Inflammation is a persistent challenge with current medical devices and implants, despite advances in biocompatible materials.
Developing effective anti-inflammatory biomaterials is crucial for improving medical device performance and patient outcomes.

Purpose of the Study:

To create patterned dextran and hyaluronic acid surfaces using microcontact printing and photodegradation.
To evaluate the anti-inflammatory properties of these patterned surfaces by studying macrophage adhesion.
To investigate the utility of binary polysaccharide patterns for high-throughput screening of anti-inflammatory biomaterials.

Main Methods:

Patterning dextran and hyaluronic acid onto glass surfaces via microcontact printing and UV-induced photodegradation.
Creating binary polysaccharide patterned surfaces by grafting hyaluronic acid onto dextranized glass.
Assessing human macrophage (THP-1) adhesion on patterned surfaces with varying geometries (90 µm squares, 22 µm stripes) over a three-day culture period.

Main Results:

Macrophages exhibited minimal adhesion to hyaluronic acid-modified surfaces.
Macrophage adhesion ranking was: 3-aminopropyl triethoxysilane (APTES)-modified glass > dextranized surfaces > glass > hyaluronic acid-modified surfaces.
On binary dextran/hyaluronic acid patterns, macrophages preferentially adhered to dextranized areas.

Conclusions:

Patterned dextran and hyaluronic acid surfaces demonstrate significant anti-inflammatory potential by reducing macrophage adhesion.
Binary polysaccharide patterns offer a versatile platform for mimicking the glycocalyx and studying cell-surface interactions.
This approach provides a novel high-throughput method for developing and evaluating anti-inflammatory biomaterial coatings.