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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 2, 2026

A Melanoma Patient-Derived Xenograft Model

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

A melanoma molecular disease model.

Smruti J Vidwans¹, Keith T Flaherty, David E Fisher

¹CollabRx Inc, Palo Alto, California, United States of America.

|April 12, 2011

Summary

This study introduces a Molecular Disease Model (MDM) for advanced melanoma, classifying tumors by molecular subtypes to guide personalized treatment strategies. This approach enhances therapeutic decisions for challenging melanoma cases.

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Last Updated: Jun 2, 2026

A Melanoma Patient-Derived Xenograft Model

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Oncology
Genetics
Personalized Medicine

Background:

Advanced melanoma presents significant therapeutic challenges.
Understanding molecular drivers is crucial for effective treatment.
Genetic analyses reveal key pathways in melanoma progression.

Purpose of the Study:

To develop a Molecular Disease Model (MDM) for melanoma.
To classify individual tumors into molecular subtypes.
To propose subtype-specific treatment guidelines.

Main Methods:

Genetic analysis of melanoma tumors.
Identification of key molecular pathways.
Development of a classification system for molecular subtypes.

Main Results:

A novel Melanoma Molecular Disease Model (MDM) has been established.
Individual tumors can be classified into distinct molecular subtypes.
Treatment guidelines incorporating assays, drugs, and trials are proposed for each subtype.

Conclusions:

The MDM offers a framework for personalized melanoma therapy.
Molecular subtyping improves upon traditional histological classification.
This model reflects the latest scientific and clinical advances in melanoma treatment.