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Updated: Jun 2, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
Published on: May 24, 2024
Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors
1Department of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield, UK. r.f.storey@sheffield.ac.uk
Abstract:
The important role of the P2Y12 receptor in amplification of platelet activation and associated responses and the limitations associated with clopidogrel therapy have led to the development of novel inhibitors of this receptor. Three reversibly-binding P2Y12 inhibitors are in phase 3 development, ticagrelor, cangrelor and elinogrel. The pharmacology and clinical trial data for each of these inhibitors are discussed and compared with relevant data for the thienopyridines clopidogrel and prasugrel.
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