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Related Experiment Video

Updated: Jun 2, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Necrotizing infundibulo-hypophysitis: an entity too rare to be true?

Angelika Gutenberg1, Patrizio Caturegli, Imke Metz

  • 1Department of Neurosurgery, University Medical Center, Georg August University, 37099, Göttingen, Germany. agutenberg@med.uni-goettingen.de

Pituitary
|April 12, 2011
PubMed
Summary

A rare pituitary inflammation, necrotizing infundibulo-hypophysitis, presented as a sellar mass causing severe headache. Histopathology confirmed this diagnosis, distinct from typical pituitary adenoma.

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Last Updated: Jun 2, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • Pituitary macroadenomas are common sellar masses, often presenting with mass effect or hormonal dysfunction.
  • Pituitary apoplexy is a clinical syndrome associated with pituitary adenomas, characterized by sudden onset of headache, visual impairment, and ophthalmoplegia.
  • Hypophysitis, inflammation of the pituitary gland, is a rare condition with several subtypes, including lymphocytic, granulomatous, and necrotizing forms.

Observation:

  • A young woman presented with sudden, severe retroorbital headache and neck pain.
  • Imaging revealed a large sellar mass extending to the suprasellar cistern.
  • Surgical exploration and subsequent histopathology were crucial for diagnosis.

Findings:

  • The presumptive diagnosis of a non-secreting pituitary macroadenoma with apoplexy was made preoperatively.
  • Histopathological examination revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary.
  • These findings were consistent with necrotizing infundibulo-hypophysitis, a rare variant of hypophysitis.

Implications:

  • This case highlights the importance of considering rare pituitary inflammatory conditions in the differential diagnosis of sellar masses.
  • Necrotizing infundibulo-hypophysitis can mimic pituitary adenoma apoplexy, necessitating thorough histopathological evaluation.
  • Understanding the pathogenesis of this rare condition may lead to improved diagnostic and therapeutic strategies for pituitary disorders.